Figure 7.

Treatment of Kal-1 brings back the levels of pro- and antihormonal levels to normal which were showing metabolic disturbed contour in high-fat high-sugar fed mice at weeks 22, 26, and 30. (a) Effect of Kal-1 treatment on leptin profile in high-fat high-sugar diet fed mice at weeks 22, 26, and 30. (b) Effect of Kal-1 treatment on high-molecular-weight adiponectin profile in high-fat high-sugar diet fed mice at weeks 22, 26, and 30. Treatment with all doses (5, 20, and 75 μL) of Kal-1 was started only after 21 weeks (induction period) along with high-fat high-sugar diet. LF: low-fat control, HF: high-fat high-sugar control. All the values represent mean ± SEM from five animals.