Figure 5.

JWH-133 protects ApoE^−/− mouse corpus cavernosum against fibrosis. Collagen content was evaluated by sirius red staining in penis from wild type and ApoE^−/− mice treated or not with JWH-133. (a) Quantification of collagen content into the corpus cavernosum. ((b)–(d)) Representative photomicrographs of penis sections showing the corpus cavernosum of wild type mice (b) and untreated (c) and treated (d) ApoE^−/− mice. *P < 0.05 (one-way ANOVA followed by the Bonferroni post-test). Each column represents the mean ± SEM (n = 9) of smooth muscle cell/collagen content ratio in arbitrary unity (A.U.).