Table 3. Enriched signalling pathways regulated in heart transplantation.

Pathway Name	EnrichmentScore	p-value Enrichment	% genesa	# genesb	# genesc	# genesd	Database
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	9.7642	5.75E-05	9.58904	7	89	6829	kegg
Calcium signaling pathway	8.48247	0.000207	5.40541	10	86	6720	kegg
Gap junction	6.56392	0.00141	6.66667	6	90	6811	kegg
Adipocytokine signaling pathway	5.81675	0.002977	6.94444	5	91	6828	kegg
Dilated cardiomyopathy	4.86527	0.00771	5.55556	5	91	6810	kegg
Energy Metabolism	4.60156	0.010036	4	7	89	6727	kegg
p53 signaling pathway	4.22517	0.014623	5.7971	4	92	6830	kegg
Insulin signaling pathway	4.17598	0.01536	4.08163	6	90	6754	kegg
Tyrosine metabolism	3.99802	0.018352	7.31707	3	93	6857	kegg
Bladder cancer	3.81036	0.02214	6.81818	3	93	6854	kegg
Hypertrophic cardiomyopathy(HCM)	3.6154	0.026906	4.81928	4	92	6816	kegg
One carbon pool by folate	3.59657	0.027418	10.5263	2	94	6878	kegg
Mineral absorption	3.52912	0.029331	6.12245	3	93	6849	kegg
Fatty acid metabolism	3.477	0.0309	6	3	93	6848	kegg
Drug metabolism - cytochromeP450	3.46478	0.03128	4.5977	4	92	6812	kegg
Type II diabetes mellitus	3.28047	0.037611	5.55556	3	93	6844	kegg
Transcriptional misregulationin cancer	3.27588	0.037784	3.31492	6	90	6720	kegg
Acute myeloid leukemia	3.01689	0.048953	5	3	93	6838	kegg

note: ^a% genes in pathway that are present;

^bnumbers of genes in list and in the pathway;

^cnumbers of genes in list, not in pathway;

^dnumbers of genes not in list, not in pathway.