Table 2. Effect of bee venom on pharmacokinetic parameters and constants of a single dose of methotrexate.
Parameters | Single MTX | Single MTX+BV |
Cmax (µg/ml) | 5.09±0.808 | 15.71*±2.646 |
AUC 0-∞ (µg.h/ml) | 110.50±28.520 | 395.60*±72.240 |
MRT(h) | 44.42±11.960 | 90.90*±14.390 |
t1/2 (h) | 30.59±8.809 | 63.77*±10.190 |
Kel (hr−1) | 0.02±0.005 | 0.01*±0.002 |
CL (ml/hr) | 1.53±0.312 | 0.42*±0.081 |
-Data is represented as means ± SD (n = 15), normal rats injected with single dose of methotrexate (Single MTX), normal rats injected with bee venom for 3 weeks followed by single dose of methotrexate (Single MTX+BV),
means significantly different from the corresponding (single MTX) group at P<0.05 using unpaired student's t-test.