. 2013 Nov 20;8(11):e79284. doi: 10.1371/journal.pone.0079284

Table 2. Effect of bee venom on pharmacokinetic parameters and constants of a single dose of methotrexate.

Parameters	Single MTX	Single MTX+BV
C_max (µg/ml)	5.09±0.808	15.71^*±2.646
AUC _0-∞ (µg.h/ml)	110.50±28.520	395.60^*±72.240
MRT(h)	44.42±11.960	90.90^*±14.390
t_1/2 (h)	30.59±8.809	63.77^*±10.190
K_el (hr⁻¹)	0.02±0.005	0.01^*±0.002
CL (ml/hr)	1.53±0.312	0.42^*±0.081

-Data is represented as means ± SD (n = 15), normal rats injected with single dose of methotrexate (Single MTX), normal rats injected with bee venom for 3 weeks followed by single dose of methotrexate (Single MTX+BV),

means significantly different from the corresponding (single MTX) group at P<0.05 using unpaired student's t-test.