Table 2. Most statistically significant Single Nucleotide Polymorphisms based on GWAS Results from Meta-Analysis of 7 Cohorts (p<1×10−5).

SNP	Chr	Position	A1	A2	Frequency (A1)	Effect	Standard Error	P-value	Effect direction	n	Heterogeneity (i2)	P-value (Hetero-geneity)	# Support SNPs*	Closest Gene (<50 kb)
rs4911015	13	84985734	A	T	0.87	−0.20	0.04	7.38E-07	−−−+−−−	11125	0.00	0.82	9
rs426691	8	55294178	C	T	0.61	−0.14	0.03	1.08E-06	−−−−−−+	11126	0.46	0.07	2
rs17825699	1	230254964	T	G	0.76	0.16	0.03	1.20E-06	+++++++	11125	0.00	0.61	0	DISC1
rs9728264	1	230291141	G	A	0.42	0.12	0.03	2.31E-06	+++++++	11125	0.11	0.88	18	DISC1
rs789651	1	230760474	A	C	0.96	−0.31	0.07	4.47E-06	−−−−−−−	11125	0.00	0.59	11	SIPA1L2
rs12787660	11	11109384	G	A	0.54	0.12	0.03	4.84E-06	+++++++	11126	0.00	0.21	7
rs10794718	10	1132750	T	C	0.47	−0.12	0.03	4.85E-06	−+−−−−−	11127	0.55	0.24	0	KIAA0982
rs3788398	22	25160478	G	A	0.95	0.26	0.06	5.17E-06	+++++++	11124	0.00	0.32	19	ASPHD2
rs12636740	3	174527418	G	A	0.75	−0.15	0.03	5.48E-06	−−−−−−−	11126	0.00	0.66	31
rs1258724	15	30848487	T	C	0.74	−0.13	0.03	6.82E-06	−−−−−−−	11127	0.00	0.97	11	FMN1

Chr = Chromosome, A1 = coded allele, A2 = non-coded allele.

^*Number of SNPs within 250 kb of indicator SNP, linkage disequilibrium threshold of R2≥0.5, and p for association <0.01.