Table 3. Meta-Analyzed R2 for the Association between the Polygenic Risk Score and Phobic Anxiety, across Seven Target Samples.
P-value threshold for SNP inclusion in polygenic risk score | R2 for polygenic risk score predicting phobic anxiety (variance explained)* | P-value for the genome-wide polygenic risk score | R2 for candidate gene risk score predicting phobic anxiety (variance explained)* | P-value for the genome-wide polygenic risk score | NagelkerkeR2 for Demirkan risk score predicting phobic anxiety∧ | P value of association of the associated score |
0.00001 | 0.000 | 0.65 | – | – | – | – |
0.0001 | 0.000 | 0.77 | – | – | 0.001 | 0.63 |
0.001 | 0.000 | 0.77 | – | – | 0.001 | 0.48 |
0.01 | 0.001 | 0.23 | 0.001 | 0.12 | 0.001 | 0.26 |
0.1 | 0.001 | 0.14 | 0.001 | 0.19 | 0.002 | 0.82 |
0.2 | 0.001 | 0.11 | 0.001 | 0.10 | 0.001 | 0.42 |
0.3 | 0.001 | 0.10 | 0.001 | 0.35 | 0.001 | 0.16 |
0.4 | 0.001 | 0.30 | 0.001 | 0.38 | 0.001 | 0.07 |
0.5 | 0.001 | 0.10 | 0.001 | 0.28 | 0.001 | 0.12 |
R2 estimates based on linear regression of phobic anxiety on polygenic risk score in each target sample, based on polygenic risk score estimates from GWAS of the other 6 samples.
NagelkerkeR2 values from logistic regressions using Demirkan score to predict dichotomized phobic anxiety phenotype.All models adjusted for eigenvectors.