Table 3. Meta-Analyzed R² for the Association between the Polygenic Risk Score and Phobic Anxiety, across Seven Target Samples.

P-value threshold for SNP inclusion in polygenic risk score	R2 for polygenic risk score predicting phobic anxiety (variance explained)*	P-value for the genome-wide polygenic risk score	R2 for candidate gene risk score predicting phobic anxiety (variance explained)*	P-value for the genome-wide polygenic risk score	NagelkerkeR2 for Demirkan risk score predicting phobic anxiety∧	P value of association of the associated score
0.00001	0.000	0.65	–	–	–	–
0.0001	0.000	0.77	–	–	0.001	0.63
0.001	0.000	0.77	–	–	0.001	0.48
0.01	0.001	0.23	0.001	0.12	0.001	0.26
0.1	0.001	0.14	0.001	0.19	0.002	0.82
0.2	0.001	0.11	0.001	0.10	0.001	0.42
0.3	0.001	0.10	0.001	0.35	0.001	0.16
0.4	0.001	0.30	0.001	0.38	0.001	0.07
0.5	0.001	0.10	0.001	0.28	0.001	0.12

^*R² estimates based on linear regression of phobic anxiety on polygenic risk score in each target sample, based on polygenic risk score estimates from GWAS of the other 6 samples.

^∧NagelkerkeR² values from logistic regressions using Demirkan score to predict dichotomized phobic anxiety phenotype.All models adjusted for eigenvectors.