Table 3. Underlying biology.
|
A. Pathways | ||||||
|---|---|---|---|---|---|---|
|
INGENUITY pathways |
KEGG pathways |
|||||
| No. | Top canonical pathways | P-value | Ratio | Pathway name | Enrichment score | Enrichment P-value |
| CFG score⩾6.0; N=21 genes | ||||||
| 1 | Role of tissue factor in cancer | 2.63E−04 | 3/115 (0.026) | Apoptosis | 6.69102 | 0.001242 |
| 2 | Dendritic cell maturation | 9.83E−04 | 3/207 (0.014) | Measles | 6.06369 | 0.002326 |
| 3 | Melanoma signaling | 1.13E−03 | 2/46 (0.043) | Endometrial cancer | 4.96787 | 0.006958 |
| 4 | DHA signaling | 1.18E−03 | 2/49 (0.041) | Influenza A | 4.90223 | 0.00743 |
| 5 | Endometrial cancer signaling | 1.69E−03 | 2/57 (0.035) | Phosphatidylinositol signaling system | 4.85448 | 0.007793 |
| CFG score⩾4.0; N=41 genes | ||||||
| 1 | NF-κB signaling | 4.42E−04 | 4/175 (0.023) | Measles | 8.7667 | 0.000156 |
| 2 | Dendritic cell maturation | 5.38E−04 | 4/207 (0.019) | Influenza A | 6.87308 | 0.001035 |
| 3 | PDGF signaling | 7.5E−04 | 3/85 (0.035) | mTOR signaling pathway | 6.34986 | 0.001747 |
| 4 | Role of pattern recognition receptors in recognition of bacteria and viruses | 1.14E−03 | 3/106 (0.028) | Apoptosis | 4.75687 | 0.008592 |
| 5 | Role of tissue factor in cancer | 1.78E−03 | 3/115 (0.026) | Toll-like receptor signaling pathway | 4.37269 | 0.012617 |
|
B. Disease and disorders | |||
|---|---|---|---|
|
INGENUITY | |||
| No. | Diseases and disorders | P-value | Number of molecules |
| CFG score⩾6.0; N=21 genes | |||
| 1 | Cancer | 1.22E−06 to 4.54E−03 | 14 |
| 2 | Connective tissue disorders | 2.19E−04 to 3.41E−03 | 8 |
| 3 | Inflammatory disease | 2.19E−04 to 4.54E−03 | 8 |
| 4 | Skeletal and muscular disorders | 2.19E−04 to 4.42E−03 | 9 |
| 5 | Gastrointestinal disease | 2.22E−04 to 4.54E−03 | 12 |
| CFG score⩾4.0; N=41 genes | |||
| 1 | Cancer | 4.51E−06 to 6.45E−03 | 20 |
| 2 | Inflammatory response | 2.70E−05 to 6.45E−03 | 12 |
| 3 | Antimicrobial response | 9.95E−05 to 6.45E−03 | 4 |
| 4 | Infectious disease | 1.25E−04 to 5.52E−03 | 6 |
| 5 | Connective tissue disorders | 1.53E−04 to 6.45E−03 | 11 |
Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes; CFG, Convergent Functional Genomics; DHA, docosahexaenoic acid; mTOR, mammalian target of rapamycin; NF-κB, nuclear factor-κB.