Table 3.
IL-12 polymorphisms in hemodialysis non-responders to hepatitis B vaccine (subgroup Ia) and hemodialysis responders to hepatitis B vaccine (subgroup Ib) with the development of antibodies to surface antigen of hepatitis B virus
| Genotype | Subgroup Ia (n = 199) n (%) | Subgroup Ib (n = 403) n (%) | OR (95 % CI) | P value |
|---|---|---|---|---|
| IL-12A | ||||
| GG | 152 (76.4) | 275 (68.2) | Referent | |
| GA | 40 (20.1) | 115 (28.5) | 1.6 (1.0–2.5)a | 0.033b |
| AA | 7 (3.5) | 13 (3.2) | 1.0 (0.6–1.7)a | 0.984 |
| GA/AA | 47 (23.6) | 128 (31.8) | 1.5 (1.0–2.3)a | 0.048b |
| AA | 7 (3.5) | 13 (3.2) | Referent | |
| GA/GG | 192 (96.5) | 390 (96.8) | 1.2 (0.4–3.2)a | 0.783 |
| Allele G | 344 (86.4) | 665 (82.5) | Referent | |
| Allele A | 54 (13.6) | 141 (17.5) | 1.4 (1.0–1.9) | 0.096 |
| IL-12B | ||||
| AA | 121 (60.8) | 231 (57.3) | Referent | |
| AC | 74 (37.2) | 160 (39.7) | 1.0 (0.7–1.5)a | 0.876 |
| CC | 4 (2.0) | 12 (3.0) | 1.1 (0.6–2.1)a | |
| AC/CC | 78 (39.2) | 172 (42.7) | 1.3 (0.4–4.5)a | 0.626 |
| CC | 4 (2.0) | 12 (3.0) | Referent | |
| AC/AA | 195 (98.0) | 391 (97.0) | 0.8 (0.2–2.6)a | 0.660 |
| AlleleA | 319 (79.6) | 622 (77.2) | Referent | |
| Allele C | 82 (20.4) | 184 (22.8) | 1.2 (0.9–1.6) | 0.387 |
aOdds ratio (OR) after adjustment for age, renal replacement therapy (RRT) vintage, and diabetic nephropathy or chronic glomerulonephritis as causes of RRT
bNon-significant after the Bonferroni correction for multiple comparisons (P > 0.017)