Table 6.
IL-12 polymorphisms in hemodialysis non-responders to hepatitis B virus (HBV) transmission (subgroup IIa) and hemodialysis responders to HBV transmission (subgroup IIb) with the development of antibodies to surface antigen of HBV
| Genotype | Subgroup IIa (n = 55) n (%) | Subgroup IIb (n = 182) n (%) | OR (95 % CI) | P value |
|---|---|---|---|---|
| IL-12A | ||||
| GG | 34 (61.8) | 130 (71.4) | Referent | |
| GA | 17 (30.9) | 48 (26.4) | 1.0 (0.4–2.2)a | 0.954 |
| AA | 4 (7.3) | 4 (2.2) | 0.6 (0.2–1.3)a | 0.182 |
| GA/AA | 21 (38.2) | 52 (28.6) | 0.8 (0.4–1.8)a | 0.660 |
| AA | 4 (7.3) | 4 (2.2) | Referent | |
| GA/GG | 51 (92.7) | 178 (97.3) | 3.1 (0.6–16.4)a | 0.177 |
| Allele G | 85 (77.3) | 308 (84.6) | Referent | |
| Allele A | 25 (22.7) | 56 (15.4) | 0.62 (0.4–1.0) | 0.083 |
| IL-12B | ||||
| AA | 39 (70.9) | 107 (58.8) | Referent | |
| AC | 9 (16.4) | 71 (39.0) | 5.7 (1.9–17.2)a | 0.002b |
| CC | 7 (12.7) | 4 (2.2) | 0.2 (0.06–0.8) | 0.015b |
| AC/CC | 16 (29.1) | 75 (41.2) | 2.7 (1.1–6.2)a | 0.022c |
| CC | 7 (12.7) | 4 (2.2) | Referent | |
| AC/AA | 48 (87.3) | 178 (97.8) | 7.0 (1.7–28.7)a | 0.006 |
| Allele A | 87 (79.1) | 285 (78.3) | Referent | |
| Allele C | 23 (20.9) | 79 (21.7) | 1.0 (0.6–1.8) | 0.896 |
a Odds ratio (OR) after adjustment for HBV surface antigen and chronic glomerulonephritis as a cause of renal replacement therapy
bSignificant after the Bonferroni correction for multiple comparisons (P < 0.017)
cNon-significant after the Bonferroni correction for multiple comparisons (P > 0.017)