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. 2013 Nov 21;7:170. doi: 10.3389/fncom.2013.00170

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Copyright © 2013 Albers, Schmiedt and Pawelzik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Best fit of CD model and Triplet model to the data in HC (A–D) and VC23 (E–H). In HC, CD model and Triplet model capture the main feature of the results, where pre-post-pre triplets do not change the synapse, while post-pre-post triplets show strong LTP. The +5, −15 triplet (B, right) however, can not be reproduced by both models, leading to a relatively large error. In VC23, adaptation is evident in (G). Adding more spikes in front of a pre-post pair decreases LTP, contrary to expectation. The Triplet model has no mechanism which can deal with that.