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. 2013 Nov 21;4:400. doi: 10.3389/fimmu.2013.00400

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Copyright © 2013 Piras, Rattazzi, McDermott, Deacon and D’Acquisto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glatiramer acetate inhibits the emotional changes of MOG_35–55-immunized mice. The graph in (A) shows the percentage of latency to rearing of vehicle-treated non-immunized mice, glatiramer acetate-(GA), or control PBS-treated mice subjected to MOG_35–55-induced EAE and assessed during the 5-min test. The values are expressed as mean percentage ± SEM of the basal activity for six to eight. **p < 0.01 indicates significant values compared to control mice. The bar graph in (B) shows the total number of T cells in the draining lymph nodes of glatiramer acetate-(GA) or control PBS-treated mice subjected to MOG_35–55-induced EAE at day 4. The results are representative of n = 6–8 mice.