Illustration of our interactive toolkit on biomedical image-based modeling and simulation (BIMoS). (A) The main display window, which can show multiple models simultaneously. Shown here is a meshed surface of the 3D cryo-electron microscopy (cryo-EM) map of the RyR1 channel [40], downloaded from the EMDataBank (ID=1275, http://emdatabank.org/). The surface mesh was first generated by marching cubes [37] followed by mesh quality improvement provided in BIMoS. (B) The property window showing a tree-like file structure with associated properties. The properties in this window are editable (for example, users can hide, show, delete a model, or change the color properties of the model). (C) The information window showing some general information about the objects and operations (e.g., running time and size of the input image or mesh). This type of information is non-editable. (D) Icons for different approaches to selecting specific regions of a mesh or image. (E) Icons for several standard view directions. (F) Icons for model transformations (selective zooming, scaling, translation, rotation). (G) Icons for different display modes (points, edges, faces, flat or smooth shading, bounding box). In addition, there is a progress bar at the bottom of the window, showing the progress (in percentage) of each running job.