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. 2013 Oct 3;154(12):4627–4639. doi: 10.1210/en.2013-1483

Figure 6.

Figure 6.

Changes in ulcer size in PC-ShhKO mice infused with exogenous Shh. A, Changes in circulating Shh concentrations in PC-ShhKO mice infused with either PBS or rmShh for 7 days after acetic acid-induced injury. B, Gross morphology of stomachs collected from PBS or rmShh infused PC-ShhKO mice. Arrows indicate ulcerated area. C, Changes in PC-ShhKO mouse ulcer size in response to either PBS or rmShh infusion for 7 days after acetic acid-induced injury. D, Gross morphology of stomachs collected from IgG or anti-Shh antibody-injected control mice. Arrows indicate ulcerated area. E, Changes in control mouse ulcer size in response to either IgG or anti-Shh antibody injections for 7 days after acetic acid-induced injury. Data are expressed as the mean ± SEM with five eight mice per group. *, P < .05 compared with PBS-infused or IgG-injected mice. F, Changes in Gli1 expression in Hedgehog-responsive cell line C3H10T1/2 in response to serum collected from either IgG- or anti-Shh antibody-injected control mice. *, P < .05 compared with no treatment (NT) (n = 5 serum samples collected from individual mice).