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. 2013 Oct 8;154(12):4607–4617. doi: 10.1210/en.2013-1737

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Copyright © 2013 by The Endocrine Society

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Figure 6. — PKA but not CAMKII mediates BPA-induced SR Ca²⁺ leak in female rat ventricular myocytes. A and D, Effect of PKA blockade with PKI and CAMKII blockade with AIP, respectively, on BPA-induced increase in diastolic Ca²⁺ sparks. B and E, Average Ca²⁺ spark frequency. cont, control. C and F, Average Ca²⁺ spark amplitude under indicated treatments. Data are averages of total 128 sparks from 10 myocytes for B and C and 206 sparks from 22 myocytes for E and F (n = 6 hearts). BPA = 1 nM for all experiments; PKI, H89, AIP, and KN93 concentration = 1 μM. *, P < .05 vs control. N.S, not significant (P > .5).