DEXA study of Wt, Mct8KO, D1KO, and Mct8D1KO mice. A, Body composition. B, Fat and lean mass expressed as percentage of total body mass. Genotypes are indicated. Asterisks represent P values by ANOVA and Newman-Keuls test. Significant differences compared with Wt animals are above the SEM bars. Comparisons of Mct8KO and Mct8D1KO are indicated by horizontal lines. *, P < .05; **, P < .01; ***, P < .001.