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. 2013 Sep 12;154(12):4777–4789. doi: 10.1210/en.2013-1476

Figure 4.

Figure 4.

Dopamine agonism suppresses secretion of both pituitary hPRL and mPRL in vivo and in vitro. (A and B) Serum was collected from bigenic (hPRL+;mPRL+) female mice 90 minutes after sc injection of Brx (2.5 mg/kg, n = 5) or vehicle (n = 7), then assayed for hPRL (A) and mPRL (B). *P < .02, Brx vs vehicle; Student's t test. (C and D) Primary cultured AP cells from bigenic male or female mice were incubated for 60 minutes with vehicle, DA (300nM), or TRH (100nM). At the end of incubation, media were collected and centrifuged, and the supernatants were assayed for hPRL (C) and mPRL (D). Data represent the means of 4 repeated experiments. *, P < .05; ***, P < .001 compared with vehicle-treated control group within the same category (sex); 1-way ANOVA followed by Bonferroni's multiple comparison test.