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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Science. 2013 Nov 7;342(6160):10.1126/science.1240585. doi: 10.1126/science.1240585

Fig.5. Role of domains III and the connecting helix 12 of eIF5B in GTPase activation.

Fig.5

(A) Details showing the interaction of domain III of eIF5B with ribosomal protein S23 from the 40S (yellow) and the base of helix 12 with the sarcin ricin loop (SRL) of the 28S rRNA (B) Zoomed-in view of the interaction between helix 12 and the SRL around residue Y838. (C) A sequence alignment of IF2 from the bacteria Escherichia coli (EC), aIF5B from the archaea Methanothermobacter thermautotrophicus (MT) and eIF5B from the eukaryotes Saccharomyces cerevisiae (SC) and humans (HM) highlights the conservation of the Y838 and surrounding residues suggesting the importance of this interaction.