Table 3.

Gray matter differences between patients and healthy controls.

Regions	Maximum		Cluster		Cluster breakdown	Jack-knife sensitivity
	Talairach coordinates	Z value	Uncorrected P	No. of voxels		No. of analyses survived by the clusters
PATIENTS > CONTROLS
Right basal ganglia (Right lentiform nucleus, putamen)	20, 2, 4	2.287	0.000064226	85	Right putamen	9 out of 9
					Right caudate body
					Right caudate head
					Right lateral globus pallidus
Left basal ganglia (Left lentiform nucleus, putamen)	−22, −2, 8	2.283	0.000064226	77	Left putamen	8 out of 9
					Left caudate body
					Left lateral globus pallidus
Right parahippocampal gyrus	38, −26, −16	2.140	0.000166988	43	Right parahippocampal gyrus	8 out of 9
					Right inferior temporal gyrus
					Right fusiform gyrus
Left precentral gyrus	−38, −8, 46	2.055	0.000616570	21	Left precentral gyrus	8 out of 9
					Left middle frontal gyrus
Left inferior temporal gyrus(Left fusiform gyrus)**	−46, −12, −30	2.053	0.000616570	36	Left inferior temporal gyrus	8 out of 9
					Left fusiform gyrus
Right cerebellar tonsil	22, −54, −34	1.831	0.002581888	13	Right cerebellar tonsil	7 out of 9
PATIENTS < CONTROLS
Right cuneus	22, −98, −2	−3.877	0.000321130	90	Right cuneus	8 out of 9
					Right lingual gyrus
					Right middle occipital gyrus
					Right inferior occipital gyrus
Right superior frontal gyrus	28, 60, 4	−3.645	0.000552344	78	Right superior frontal gyrus	7 out of 9
					Right middle frontal gyrus
Right insula	42, 2, 12	−3.179	0.001451509	40	Right insula	8 out of 9
					Right superior temporal gyrus
					Right precentral gyrus
Left basal ganglia (Left clastrum)**	−30, 16, 2	−3.132	0.001592807	49	Left clastrum	7 out of 9
					Left superior temporal gyrus
					Left insula
					Left extra-nuclear

**Shared GM alterations in patients and their unaffected relatives.