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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Syst Biol Reprod Med. 2010 Apr;56(2):10.3109/19396360903431638. doi: 10.3109/19396360903431638

FIGURE 5.

FIGURE 5

Spatial confines of TSC differentiation. TSC differentiation is affected by stress globally on an mRNA level in a manner suggesting activation of early differentiation of lineages occurring spatially early after implantation. PL1 transcripts that are markers of placental lineage (primary trophoblast giant cells) that initially contact maternal vasculature are induced by stress [Liu et al. 2009]. Markers for later placental lineages such as the labyrinthine (glial cells missing; GCM) and spongiotrophoblast (TGBP1) are not detected. The secondary trophoblast giant cell lineage arising soon after the primary trophoblast giant cell lineage is detected as a partial phenotype (GATA2, STRA13, and proliferin, but not PLII and PLPA).