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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Oncogene. 2009 Nov 9;29(5):10.1038/onc.2009.373. doi: 10.1038/onc.2009.373

Figure 8.

Figure 8

Synergistic activation of a genomic peroxisome proliferator-activated receptor-γ (PPARγ) promoter fragment by androgen receptor (AR) and CCAAT enhancer binding protein-α (C/EBPα) through a chromatin site in intron 1 identified using chromatin immunoprecipitation-DNA microarray chip (ChIP-chip). HeLa cells were transfected with the pGL3-basic vector in which genomic DNA fragments corresponding to the indicated PPARγ gene sequences were inserted upstream of the luciferase reporter. The cells were co-transfected with an expression plasmid for AR or vector control and/or C/EBPα expression plasmid or vector control for 48h. The relative promoter activities are plotted as the ratio to that of the corresponding promoter in the absence of AR and ectopic C/EBPα. The P-values for the differences noted in the text were <0.001.