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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Cell Biol. 2013 May 26;15(6):10.1038/ncb2756. doi: 10.1038/ncb2756

Figure 7.

Figure 7

Model outlining the role of YAP in the generation and maintenance of CAFs. A range of soluble factors can promote matrix remodelling by normal fibroblasts. This requires some level of ROCK and actomyosin function. As the matrix becomes stiffer, isometric tension within the cell increases leading to Src activation and the association of YAP with TEAD transcription factors. Active YAP then promotes the expression of ANLN and DIAPH3 and stabilises actomyosin proteins. This leads to further matrix stiffening, thereby generating a positive feedback loop.