Figure 2.

Human Aβ_1–42 does not reduce LTP in slices of Tau^−/− mice. a, b, Hippocampal Schaffer collateral-CA1 LTP in wild-type (a) and Tau^−/− mice (b) in control ACSF (black), or after incubation with hAβ_1–42 (red) or the control peptide hAβ_42–1 (gray). The insets show superimposed example traces before and 40 min after high-frequency stimulation for each condition. Scale bars: 5 ms, 200 μV. c, Summary of results 40–45 min after high-frequency stimulation. Error bars are SEM; **p < 0.01. The numbers of slices are shown in parentheses.