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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Cancer Res. 2009 Apr 7;69(8):10.1158/0008-5472.CAN-08-4884. doi: 10.1158/0008-5472.CAN-08-4884

Figure 3. Effect of PI-103 and rapamycin on critical components of the PI3K/AKT/mTOR signaling pathway.

Figure 3

A: cells were treated with PI-103 (0.75 µM) or rapamycin (0.1 µM), collected, and then lysed. Fifty micrograms of each lysate were electrophoresed on SDS-PAGE gels. B: Treatment with PI-103 for 8 h induced a dose-dependent dephosphorylation of Akt on Ser473 and of 4E-BP1 in CEM-R cells treated for 8 h. In A and B one representative of three different experiments is shown