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. 2013 Dec;347(3):727–736. doi: 10.1124/jpet.113.207472

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Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 7. — ATP-dependent uptake of (A) 20 μM [³H]estradiol-17-β-D-glucuronide (E₂17G) or (B) 2 μM [³H]dehydroepiandrosterone sulfate (DHEAS) in membrane vesicles from nontransfected (NT) and MRP3- or MRP4-overexpressing (control) human embryonic kidney (HEK293T) cells, respectively, and inhibition by 50 μM rosuvastatin (RSV) and MK-571. (C) Time-dependent transport of [³H]RSV in membrane vesicles from NT (●) MRP3- (▲) and MRP4- (▪) overexpressing cells. (D) Concentration-dependent transport of RSV in membrane vesicles from MRP4-overexpressing HEK293T after subtracting endogenous ATP-dependent uptake in vesicles from NT cells; V_max and K_m values were obtained from nonlinear regression analysis. In all cases, data represent mean ± S.D. of triplicate measurements in a single experiment.