Fig. 4.

Effect of DBH inhibitors on the discriminative stimulus effects of the selective NET inhibitor reboxetine in rats trained to discriminate 5.6 mg/kg cocaine from saline. Disulfiram (left panels) or nepicastat (right panels) was administered 2 hours prior to the onset of a test session in which reboxetine was cumulatively administered across multiple components. Shown is the mean ± S.E.M. of percentage cocaine-appropriate responding (top panels) and response rate (bottom panels). Data points above “Sal” and “Coc” (filled circles) depict averaged data acquired after administration of saline or the training dose of 5.6 mg/kg cocaine during training sessions, respectively. n = 7–8.