TABLE 1.

ED₅₀ values for cocaine and number of animals meeting response criteria after pretreatment with disulfiram or nepicastat

Data are presented as ED₅₀ values with 95% confidence limits and the number of animals responding.

Pretreatment	Cocaine ED50	Animals Responding
Disulfiram
Vehicle	3.54 (3.04–4.04)	8
10 mg/kg	2.69 (1.93–3.41)	8
30 mg/kg	1.68 (0.91–2.46)a	8
100 mg/kg	1.32 (0.40–2.24)a	7
Nepicastat
Vehicle	3.54 (3.04–4.04)	8
3 mg/kg	2.77 (1.55–3.99)	8
10 mg/kg	2.73 (1.69–3.78)	8
30 mg/kg	1.99 (0.32–3.65)	5
56 mg/kg	2.05 (0.50–3.59)	4

^aP < 0.05 compared with vehicle.