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(A) Plasma concentration-time profiles of sunitinib after a single oral dose (20 mg/kg) in FVB wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice. (B) Corresponding brain concentration-time profiles of sunitinib after a single oral dose (20 mg/kg) in FVB wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice. (C) Brain-to-plasma ratios with time in wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice.
