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(A) Steady-state plasma concentrations of sunitinib after a continuous intraperitoneal infusion at 30 µg/h for 48 hours in wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice. (B) Corresponding steady-state brain concentrations of sunitinib in wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice. (C) Steady-state brain-to-plasma ratios of sunitinib.
