. 2013 Dec;347(3):755–764. doi: 10.1124/jpet.113.208959

TABLE 2.

Steady-state plasma and brain concentrations of sunitinib in wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)Bcrp1(−/−) mice after a constant intraperitoneal infusion of sunitinib at a rate of 30 µg/h for 48 hours (n = 4 each group)

Data presented as the mean ± S.D.

Genotype	Plasma Css	Brain Css	Brain-to-Plasma Ratio
	µg/ml	µg/g
FVB wild type	0.19 ± 0.16	0.09 ± 0.06	0.51 ± 0.26
Mdr1a/b(−/−)	0.18 ± 0.15	0.39 ± 0.36	2.33 ± 0.56^a
Bcrp1(−/−)	0.19 ± 0.19	0.09 ± 0.04	0.73 ± 0.44
Mdr1a/b(−/−)Bcrp1(−/−)	0.26 ± 0.09	4.46 ± 1.66^a	17.44 ± 5.08^a

P < 0.005 compared with wild type.