TABLE 3.
Brain-to-plasma ratios of sunitinib in all genotypes after a single oral dose (20 mg/kg), steady-state concentration ratios after a continuous intraperitoneal infusion (rate equal to 30 µg/h), at transient steady state (calculated as the maximum brain concentration to the corresponding plasma concentration in each genotype), and concentration ratios determined at 1 hour post oral dose (20 mg/kg) in each genotype
Data are presented as the mean ± S.D.
| Genotype | AUC0∞, PO | Css Steady State i.p. | Transient Steady State | Ratio at 1 h |
|---|---|---|---|---|
| FVB wild type | 0.42 | 0.51 ± 0.26 | 0.66 ± 0.17 | 0.42 ± 0.09 |
| Mdr1a/b(−/−) | 1.61 | 2.33 ± 0.56 | 2.42 ± 1.42 | 1.76 ± 0.65 |
| Bcrp1(−/−) | 0.88 | 0.73 ± 0.44 | 1.09 ± 0.38 | 0.24 ± 0.20 |
| Mdr1a/b(−/−)Bcrp1(−/−) | 20.53 | 17.44 ± 5.08 | 12.83 ± 1.26 | 8.14 ± 3.47 |
PO, orally.