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. 2013 Dec;347(3):669–680. doi: 10.1124/jpet.113.208421

Fig. 3.

Fig. 3.

The PI3K inhibitors LY294002 and PX-867 reduce radiation-induced apoptosis. NCCIT cells were exposed to 0 (▪) or 4 (○) Gy γIR and 1 hour later were treated with 0.1% DMSO vehicle control or various concentrations of AS-252424 (A), AS-605240 (B), BEX-235 (C), GDC-0980 (D), GSK-1059615 (E), LY294002 (F), PI-103 (G), PX-867 (H), and ZSTK474 (I). After 48 hours, caspase 3/7 activity was determined. N = 3. Bars = S.E.M. Data analyzed by ANOVA. *P < 0.05 between 4 Gy γIR exposed cells treated with DMSO vehicle or the PI3K inhibitor. +P < 0.05 between nonirradiated cells treated with DMSO vehicle or PI3K inhibitor, which would represent compound-related apoptotic effects.