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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Structure. 2013 Sep 3;21(9):10.1016/j.str.2013.08.011. doi: 10.1016/j.str.2013.08.011

Figure 2.

Figure 2

Structure of p300 core fragment. Individual domains colored as in figure 1. Certain p300 mutations found in cancer map to the newly discovered auto inhibitory RING domain. C1204R coordinates a zinc atom in the RING domain itself, whereas E1242 and R1645 form a salt bridge between the RING and HAT domains. (PDB ID 4BHW)