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Schematic representation of the two-step activation of DOX by 1) the hydrolysis of DOX-propGA3 and concomitant release of DOX-GA3 from micelles or free polymer-prodrug conjugates (which exist in a dynamic equilibrium), and 2) enzymatic conversion of DOX-GA3 into free DOX (A). Release profiles of DOX-GA3 and DOX from PEG-pHPMAm-based polymeric micelles in the absence (B) and presence (C) of β-glucuronidase.
