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Cell viability was measured with SRB assay reagent after compound exposure for 48 h.
| Cell line | PS-341 (nM) | PS341-BP-1 (nM) | PS341-BP-2 (nM) | MG-262 (nM) | MG-262 BP (nM) |
|---|---|---|---|---|---|
| 5TGM1 | 6.78+0.57 | 7.59+ 0.68 | 9.39+ 0.78 | 9.18+0.54 | 4.89+ 0.12 |
| RPMI8226 | 9.50+ 0.48 | 10.18+ 0.87 | 11.51+ 0.92 | 13.76+ 0.89 | 12.47+ 0.87 |
* IC50 values were determined in each of the cell lines from a graph of at least six drug concentrations that span the entire curve of growth inhibition as means of 3 independent experiments ±SD.
