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Sequences of various Vβ22 mutants. PS5-1, PS5-2 and PS5-4 represent stabilized Vβ22 mutants isolated from error-prone library. These mutants were used as templates to generate CDR2 libraries used to isolate four different mutants, PS7-1, PS7-2, PS7-4 and PS7-6, after sorting multiple rounds with biotinylated-SEA. Two mutations (F49M and L30S) were introduced into PS7-1 to yield the mutant designated FL. Mutated residues are in bold; CDR regions are highlighted.
