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. 2013 Jul 30;208(12):2067–2074. doi: 10.1093/infdis/jit331

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© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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Figure 3. — [¹²⁵I]Iodo-DPA-713 localizes to tuberculosis lesions. The transverse, coronal, and sagittal images from a representative Mycobacterium tuberculosis–infected C3HeB/FeJ mouse that underwent both [¹²⁵I]iodo-DPA-713 single-photon emission computed tomography–high-resolution CT (SPECT-CT) and [¹⁸F]FDG positron emission tomography (PET)–high-resolution CT are shown. Discrete areas of [¹²⁵I]iodo-DPA-713 SPECT signal are noted in the lungs of the infected mouse. The SPECT signal colocalizes with the tuberculosis lesion seen on CT (crosshair). The [¹⁸F]FDG PET signal is more diffuse, with intense signal noted in the heart, obscuring the pericardiac regions. [¹²⁵I]iodo-DPA-713 SPECT signal is also noted in the brown fat (BF) in the coronal view.