Table 1.
Tissue Biodistribution of [125I]iodo-DPA-713
| Organ(s) | BALB/c Mice, SUV, Median (Range) |
C3HeB/FeJ Mice, SUV, Median (Range) |
||||
|---|---|---|---|---|---|---|
| Uninfected | Infected | Infected (Auto-Blockade) | Uninfected | Infected | Infected (Auto-Blockade) | |
| Lung:liver | 5.01 (4.60–6.00) | 6.04 (5.56–6.99) | 2.46 (1.81–2.82) | 4.94 (4.52–6.25) | 8.38 (5.68–14.22) | 2.75 (1.12–4.57) |
| Lunga:liver | 3.86 (3.34–4.29) | 7.55 (5.39–8.33) | 2.38 (0.32–3.48) | … | … | … |
| Lung | 0.90 (0.83–1.08) | 1.01 (0.93–1.17) | 0.11 (0.00–0.12) | 0.49 (0.45–0.50) | 0.71 (0.48–1.20) | 0.12 (0.00–0.21) |
| Lunga | 0.70 (0.60–0.77) | 1.26 (0.90–1.39) | 0.10 (0.01–0.15) | … | … | |
| Liver | 0.18 (0.16–0.22) | 0.17 (0.16–0.17) | 0.04 (0.04–0.06) | 0.10 (0.08–0.10) | 0.08 (0.07–0.11) | 0.05 (0.03–0.06) |
| Blood | 0.02 (0.02–0.03) | 0.02 (0.01–0.02) | 0.01 (0.00–0.04) | 0.01 (0.00–0.01) | 0.01 (0.01–0.01) | 0.01 (0.00–0.02) |
| Heart | 0.55 (0.40–0.65) | 0.48 (0.47–0.51) | 0.04 (0.02–0.05) | 0.25 (0.24–0.26) | 0.19 (0.14–0.24) | 0.04 (0.02–0.05) |
| Stomach | 0.69 (0.64–0.81) | 0.66 (0.60–0.73) | 0.09 (0.06–0.09) | 0.38 (0.20–0.25) | 0.21 (0.19–0.33) | 0.04 (0.05–0.22) |
| Pancreas | 0.40 (0.34–0.44) | 0.40 (0.35–0.44) | 0.03 (0.02–0.04) | 0.24 (0.48–0.54) | 0.18 (0.16–0.23) | 0.03 (0.02–0.04) |
| Spleen | 0.96 (0.83–1.04) | 0.95 (0.84–1.02) | 0.09 (0.08–0.11) | 0.54 (0.76–0.95) | 0.44 (0.31–0.50) | 0.06 (0.04–0.08) |
| Kidney | 1.68 (1.37–1.86) | 1.58 (1.51–1.66) | 0.15 (0.11–0.16) | 0.94 (0.27–0.36) | 0.76 (0.66–0.93) | 0.10 (0.06–0.13) |
| Brown fat | 1.47 (1.05–1.59) | 1.02 (0.95–1.33) | 0.26 (0.20–0.31) | 0.35 (0.39–0.52) | 0.41 (0.19–0.54) | 0.10 (0.04–0.13) |
| Small intestine | 0.66 (0.50–0.80) | 0.71 (0.65–0.97) | 0.08 (0.06–0.18) | 0.40 (0.48–0.67) | 0.41 (0.30–0.46) | 0.05 (0.03–0.12) |
| Large intestine | 0.99 (0.89–1.12) | 1.09 (1.09–1.14) | 0.24 (0.15–0.37) | 0.54 (0.14–0.17) | 0.39 (0.37–0.47) | 0.18 (0.09–0.28) |
| Muscle | 0.41 (0.24–0.53) | 0.39 (0.35–0.41) | 0.02 (0.02–0.03) | 0.17 (0.19–0.23) | 0.11 (0.09–0.14) | 0.01 (0.01–0.02) |
| Bladder | 0.33 (0.31–0.36) | 0.21 (0.16–0.28) | 0.13 (0.11–0.17) | 0.21 (0.07–0.12) | 0.16 (0.11–0.21) | 0.08 (0.04–0.16) |
| Bone | 0.28 (0.25–0.31) | 0.24 (0.19–0.27) | 0.02 (0.00–0.02) | 0.09 (0.13–0.27) | 0.07 (0.06–0.09) | 0.01 (0.01–0.03) |
| Ovary | 0.46 (0.43–0.52) | 0.42 (0.29–0.57) | 0.09 (0.05–0.10) | 0.23 (0.01–0.01) | 0.19 (0.09–0.27) | 0.07 (0.05–0.10) |
| Brain | 0.02 (0.02–0.02) | 0.02 (0.01–0.02) | 0.00 (0.00–0.00) | 0.01 (0.01–0.01) | 0.01 (0.01–0.01) | 0.00 (0.00–0.00) |
Standardized uptake values (SUVs) were calculated for all tissues as the percentage of injected dose per gram of tissue per body weight.
a SUV data are calculated as the percentage of injected dose per organ per body weight for uninfected BALB/c mice, to correct for pulmonary edema noted in the infected BALB/c mice.