Figure 3.
Gene network associated with GPCR signaling correlates negatively with EAE. Expression traits with neighboring locations are drawn next to each other. eQTLs are indicated by their rat chromosome location on a second line and cis-eQTLs are indicated in white. eQTLs within EAE QTLs are indicated by a grey box with the QTL name listed in parentheses. Predicted hub genes are presented in orange and the black arrow heads indicate a directed interaction. Plus and minus indicate association to EAE phenotype. Genes with a higher disease association are placed to the right, whereas causative genes are placed toward the left.