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. 2013 Nov 14;8:127–136. doi: 10.4137/BMI.S13154

Figure 5.

Figure 5

Diagnostic values of miRNA quantification by digital PCR in plasma. The ROC and AUC were used to determine sensitivity and specificity of each miRNA. AUC for each miRNA conveyed its accuracy in differentiating lung cancer patients from the control subjects in terms of sensitivity and specificity. A. ROC curve analysis of copy numbers of the miR-21–5p in plasma of the 36 lung cancer patients and 38 cancer-free individuals produced 0.79 AUC value. B. miR-335–3p created 0.71 AUC value. C. Combined quantification of miR-21–5p and miR-335–3p by digital PCR produced 0.86 AUC that was statistically higher than that of individual one used alone. Analysis of the two miRNAs generated a sensitivity of 71.8% and a specificity of 80.6% in differentiating NSCLC patients from the cancer-free subjects.