Fig. 1.

FMDV disrupts membranes of the ERGIC and Golgi. IBRS2 cells were mock-infected (mock) or infected (m.o.i. 0.5) with FMDV for 3 h and processed for confocal microscopy. (a–c) A typical mock-infected cell co-labelled for the ERGIC (ERGIC-53: green), FMDV 3A (using 2C2: cyan) and ER (ERp57: red). (d–f) An FMDV-infected cell labelled as in (a–c). (g–i) A typical mock-infected cell co-labelled for the Golgi (Giantin: green), FMDV 3A (2C2: cyan) and ER (ERp57: red). (j–l) An FMDV-infected cell labelled as in (g–i). Cell nuclei are shown in blue. Each image shows a projection of 14 sections; spacing 0.5 μm. Bars, 10 μm.