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. 2013 Apr 25;9(2):220–229. doi: 10.12965/jer.130003

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© 2013 Korean Society of Exercise Rehabilitation

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Effect of treadmill exercise on the activation of reelin signaling pathway in the hippocampus. Upper: Photomicrographys of reelin expression and 5-bromo-2’-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus. The scale bar represents 50 μm (left) and 10 μm (right). Lower: Western blot analysis of reelin, phosphatidylinositol-3-kinase (PI3K), phosphorylated Akt (p-Akt), and phosphorylated extracellular signal-regulated protein kinase 1 and 2 (p-ERK1/2) in the hippocampus. (A) Control group, (B) control and exercise group, (C) valproic acid (VPA)-treated group, (D) VPA-treated and treadmill exercise group. The data are represented as the mean±SEM. Symbols a, b, c represent statistical significance (P<0.05) in each group.