Figure 5.

Alcohol-stimulated increases in lung slice airway CBF are enhanced in DDAH mice. Precision-cut lung slices from both wild type (WT) and dimethylaminohydrolase (DDAH) expressing mice were treated with alcohol, and their maximal CBF stimulation peaks were recorded. Alcohol (EtOH; 100 mM) significantly stimulated CBF in slices from both mice. Alcohol-stimulated CBF was significantly enhanced in DDAH (30 min) versus WT lung slices (1 hr). Bars represent SEM of triplicate separate experiments (n = 3).