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. 2013 Dec;24(Suppl 10):x7–x15. doi: 10.1093/annonc/mdt462

Figure 1.

Figure 1.

Whole-genome expression profiling of clear-cell ovarian carcinomas. (A) Graphic representation of whole-genome expression profiling of the specimens from clear-cell ovarian carcinoma (CCOC) and ovarian surface epithelium (OSE). (B) Pathway analysis of differentially regulated genes identified by the transcriptome profiling. Genes included in the analysis were required to have a fold change ≥1.5 (over OSE). Multiple probe sets were averaged for each gene. (C) Effect of a 2-week treatment with sunitinib on growth of subrenal capsule xenografts in NOD-SCID mice (6 mice/group; 2 grafts per kidney) of transplantable high-grade serous (HGSC) and clear-cell ovarian carcinoma (CCOC) tissue lines derived from patients' cancers. Growth of the xenografts is expressed as tumor volume. Data are presented as means ± SEM. (D) Effect of sunitinib on microvessel density of subrenal capsule xenografts in NOD-SCID mice of serous (HGSC) and clear-cell (CCOC) ovarian carcinoma tissue lines. Data are presented as the average number of blood vessels per 400× microscopic field ± SEM. *P < 0.01 Adapted from Stany et al. [21].