Table 1.
Association between PIK3CA mutation and sensitivity to saracatinib in colorectal cancer cell lines, colorectal cancer explants, and colorectal cancer cell lines and explants combined.
| Saracatinib- resistant |
Saracatinib- sensitive |
|
|---|---|---|
| Colorectal cancer cell lines | ||
| PIK3CA wild-type | 14 | 0 |
| PIK3CA mutant | 6 | 3 |
| P = 0.0474 | ||
| Colorectal cancer explants | ||
| PIK3CA wild-type | 13 | 0 |
| PIK3CA mutant | 2 | 2 |
| P = 0.0441 | ||
| Combined (colorectal cancer cell lines and explants) | ||
| PIK3CA wild-type | 27 | 0 |
| PIK3CA mutant | 8 | 5 |
| P = 0.0020 | ||
NOTE: P < 0.05 was considered significant.