Table 3. Association between TAS2R haplotypes/genotypes and select mean dietary intakes†.
| AVI/AVI (n=499) | PAV/AVI (n=916) | PAV/PAV (n=570) | Ppart-adj†† | Pfull-adj†† | ||||
|---|---|---|---|---|---|---|---|---|
| TAS2R38 | Mean | 95%, CI | Mean | 95%, CI | Mean | 95%, CI | ||
| Dietary fiber | 19.1 | 19.0,19.1 | 19.4 | 19.3,19.5 | 19.1 | 19.1,19.2 | 0.929 | 0.939 |
| Vegetables | 340.1 | 339.7,340.5 | 342.7 | 342.4,343.0 | 347.4 | 347.1,347.8 | 0.478 | 0.496 |
| Vegetables (no legumes) | 295.7 | 295.3,296.1 | 295.9 | 295.6,296.2 | 305.0 | 304.6,305.3 | 0.288 | 0.312 |
| Dark green vegetables | 48.6 | 48.3,48.8 | 49.8 | 49.6,50.0 | 51.7 | 51.4,51.9 | 0.244 | 0.265 |
| Cruciferous vegetables | 36.3 | 36.0,36.5 | 37.0 | 36.9,37.2 | 40.7 | 40.5,41.0 | 0.047 | 0.052 |
| Fruit | 253.2 | 252.6,253.8 | 270.6 | 270.1,271.0 | 253.8 | 253.3,254.3 | 0.963 | 0.844 |
| Citrus fruits | 57.9 | 57.4,58.4 | 60.3 | 60.0,60.7 | 59.1 | 58.6,59.5 | 0.842 | 0.910 |
| Alcohol (mg/d) | 61.2 | 62.3,64.1 | 53.3 | 52.6,54.0 | 57.9 | 57.1,58.7 | 0.628 | 0.660 |
|
| ||||||||
| CC (n=903) | AC (n=923) | AA (n=263) | Ppart-adj | Pfull-adj | ||||
| TAS2R16 (rs846672) | Mean | 95%, CI | Mean | 95%, CI | Mean | 95%, CI | ||
|
| ||||||||
| Dietary fiber | 19.5 | 19.5,19.6 | 19.2 | 19.2,19.3 | 18.8 | 18.7,18.9 | 0.144 | 0.184 |
| Vegetables | 346.5 | 346.2,346.8 | 342.0 | 341.7,342.3 | 342.5 | 341.9,343.0 | 0.607 | 0.670 |
| Vegetables (no legumes) | 299.7 | 299.4,299.9 | 296.7 | 296.5,297.0 | 300.8 | 300.3,301.3 | 0.922 | 0.974 |
| Dark green vegetables | 52.0 | 51.8,52.2 | 48.3 | 48.1,48.45 | 49.9 | 49.5,50.2 | 0.181 | 0.216 |
| Cruciferous vegetables | 39.4 | 39.2,39.6 | 36.5 | 36.3,36.7 | 39.2 | 38.8,39.6 | 0.422 | 0.437 |
| Fruit | 268.7 | 268.3,269.1 | 260.0 | 259.6,260.5 | 250.2 | 249.4,250.9 | 0.168 | 0.171 |
| Citrus fruits | 60.4 | 60.0,60.8 | 61.0 | 60.6,61.4 | 49.6 | 48.9,50.3 | 0.169 | 0.206 |
| Alcohol (mg/d) | 59.8 | 59.1,60.5 | 57.1 | 56.5,57.8 | 50.5 | 49.2,51.7 | 0.405 | 0.425 |
|
| ||||||||
| TT (n=625) | TC (n=923) | CC (n=533) | Ppart-adj | Pfull-adj | ||||
| TAS2R50 (rs1376251) | Mean | 95%, CI | Mean | 95%, CI | Mean | 95%, CI | ||
|
| ||||||||
| Dietary fiber | 19.4 | 19.4,19.5 | 19.6 | 19.6,19.7 | 18.4 | 18.3,18.4 | 0.027 | 0.013 |
| Vegetables | 355.4 | 355.0,355.8 | 345.9 | 345.6,347.2 | 323.2 | 322.8,323.6 | 0.005 | 0.004 |
| Vegetables (no legumes) | 306.1 | 306.1,306.7 | 299.3 | 299.1,299.6 | 285.0 | 284.6,285.4 | 0.028 | 0.026 |
| Dark green vegetables | 50.5 | 50.2,50.7 | 50.7 | 50.5,50.9 | 48.5 | 48.2,48.8 | 0.508 | 0.449 |
| Cruciferous vegetables | 38.8 | 38.6,39.0 | 38.3 | 38.1,38.5 | 37.2 | 36.9,37.5 | 0.521 | 0.519 |
| Fruit | 265.8 | 265.3,266.4 | 263.4 | 263.0,263.8 | 255.1 | 254.4,255.7 | 0.447 | 0.295 |
| Citrus fruits | 58.9 | 58.4,59.4 | 58.5 | 58.1,58.9 | 61.7 | 61.1,62.2 | 0.648 | 0.774 |
| Alcohol (mg/d) | 64.5 | 63.6,65.3 | 54.8 | 54.1,55.5 | 53.8 | 52.8,54.8 | 0.314 | 0.478 |
The p for trend is based on the F test (general linear models) for a variable assigned the dosage of the haplotype or variant allele.
†
Dietary variables are presented as geometric means (grams/day unless otherwise noted) and are energy-adjusted.
††
Mean intakes are partially adjusted for case status, race, age, and sex and fully adjusted for case status, race, age, sex, smoking status, lifetime smoking (pack-years), and family history of colorectal cancer.