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Physicochemical characteristics of aluminium hydroxide and adjuvanted cationic liposomes after mixing with HA.
| Formulation | Molar-ratio | HA/liposomes (HA/alum) | ||||
|---|---|---|---|---|---|---|
| Zave (nm) | Pdi | ZP (mV) | LE adj (%) | LE HA(%) | ||
| Al(OH)3 | - | 5,624 (±543) | 0.34 (±0.09) | +2.7 (±0.3 ) | - | - |
| DC-Chol:DPPC + CpG | 1:1 | 177 (±4) | 0.10 (±0.04) | +46.2 (±0.6) | 99 | 30 (±9) |
| DC-Chol:DPPC + Imiquimod | 1:1 | 168 (±3) | 0.09 (±0.02) | +43.6 (±2.6) | 100 | 60 (±2) |
Results are expressed as average ± standard deviation (n = 3 independent batches).
