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. Author manuscript; available in PMC: 2014 Nov 15.
Published in final edited form as: J Immunol. 2013 Oct 14;191(10):10.4049/jimmunol.1302079. doi: 10.4049/jimmunol.1302079

Figure 8. Model of KIR2DL4 functional modulation by HS/HSPG.

Figure 8

Interaction of KIR2DL4 with the HSPG syndecan 4 (SDC4) on the cell surface triggers endocytosis to the Rab5+ early endosome compartment to induce spontaneous activation signaling in HEK293T cells. We predict that KIR2DL4 can be recycled back to the cell surface from early endosomes. If cells are exposed to exogenous HS, this displaces SDC4 from interacting and KIR2DL4 is instead endocytosed to Rab7+ late endosomes for subsequent lysosomal degradation.