Table 1. siGENOME and Validation screen: prioritized Hit list.

Each gene is characterized by the average primary score (Whole Genome SMARTPool siRNA screen) and average score for each individual siRNA from the corresponding SmartPool. Validation index is indicating the number of “positive” out of 4 individual siRNAs, targeting each gene, which effectively reduced KIR2DL4-Ig binding in the validation screen.

Gene Symbol	Accession No.	Av. Primary Score	Av. Score siRNA I	Av. Score siRNA II	Av. Score siRNA III	Av. Score siRNA IV	Validation Index
BSG	NM_001728	0.61	0.70	1.14	0.98	0.89	1/4
CD63	NM_001780	0.69	0.75	1.06	1.01	0.91	1/4
CDH11	NM_001797	0.63	1.31	1.09	1.08	1.60	0/4
CDH3	NM_001793	0.67	1.15	1.29	1.40	2.02	0/4
CEACAM4	NM_001817	0.67	1.22	1.45	0.75	1.82	1/4
CEECAM1	NM_016174	0.61	1.18	1.14	0.64	0.89	1/4
CNTN5	NM_014361	0.59	1.02	0.89	1.00	1.12	0/4
DKFZP761O0113	NM_018409	0.42	1.13	1.08	0.98	0.90	0/4
FSTL3	NM_005860	0.52	1.03	1.21	0.74	1.19	1/4
HLA-A	NM_002116	0.75	0.89	1.91	1.07	1.50	0/4
HLA-G	NM_002127	0.68	0.73	1.03	1.02	1.02	1/4
HLA-E	NM_005516	0.71	1.38	0.83	0.97	1.14	0/4
HS3ST3B1	NM_006041	0.51	0.79	0.72	0.96	0.46	3/4
KRTAP22-1	NM_181620	0.44	0.92	1.33	1.11	0.97	0/4
LIFR	NM_002310	0.59	1.22	1.07	1.27	1.13	0/4
LOC347541	XM_293407	0.51	1.17	1.45	1.60	1.85	0/4
LRIG1	NM_015541	0.49	0.84	1.05	1.18	0.90	0/4
MICA	NM_000247	0.68	1.22	0.83	1.53	2.08	0/4
MICB	NM_005931	0.69	0.96	1.21	0.81	0.61	1/4
NAGLU	NM_000263	0.54	1.06	1.46	1.73	1.83	0/4
PCDHA2	NM_018905	0.35	0.78	0.94	0.96	1.02	1/4
PVRL4	NM_030916	0.48	1.17	1.17	1.55	1.02	0/4
SGCA	NM_000023	0.52	0.90	1.28	1.80	0.79	1/4
ULBP2	NM_025217	0.62	1.19	1.19	0.98	1.71	0/4