Table S2.
Volumetric variables presented within models containing age and total brain volume as covariates
| Regions | Contrast | df1 | df2 | t | P-value | d |
|---|---|---|---|---|---|---|
| Fourth ventricle | sAL < sNA | 1 | 9 | 2.93 | 0.02 | 1.77 |
| R inferior lateral ventricle | nsAL < sAL | 1 | 10 | 2.51 | 0.03 | 1.45 |
| R inferior lateral ventricle | nsNA < sAL | 1 | 10 | 3.59 | 0.005 | 2.07 |
| L accumbens area | nsNA < nsAL | 1 | 10 | 2.33 | 0.05 | 1.35 |
| L pallidum* | sNA < nsNA | 1 | 9 | 3.47 | 0.007 | 2.09 |
| L pallidum* | nsAL < nsNA | 1 | 10 | 4.76 | 0.0008 | 2.75 |
| L pallidum* | sAL < nsNA | 1 | 10 | 2.95 | 0.01 | 1.70 |
| L ventral diencephalon | sAL < nsNA | 1 | 10 | 2.98 | 0.01 | 1.72 |
| R amygdala | sNA < nsNA | 1 | 9 | 2.42 | 0.04 | 1.46 |
| R amygdala | sAL < nsNA | 1 | 10 | 3.91 | 0.003 | 2.26 |
| R pallidum | nsAL < nsNA | 1 | 10 | 2.67 | 0.02 | 1.54 |
| R thalamus proper | sNA < nsNA | 1 | 9 | 2.45 | 0.04 | 1.48 |
| R ventral diencephalon | sAL < nsNA | 1 | 10 | 3.16 | 0.01 | 1.82 |
| Total subcortical gray matter | sAL < nsNA | 1 | 10 | 2.29 | 0.05 | 1.32 |
| L caudal middle frontal | nsAL < sNA | 1 | 9 | 2.70 | 0.02 | 1.63 |
| L fusiform | sNA < nsAL | 1 | 9 | 3.13 | 0.01 | 1.89 |
| L paracentral | nsAL < nsNA | 1 | 10 | 4.00 | 0.003 | 2.31 |
| L paracentral | sAL < nsNA | 1 | 10 | 3.81 | 0.003 | 2.20 |
| L parahippocampal | sAL < sNA | 1 | 9 | 3.50 | 0.007 | 2.11 |
| L parahippocampal | sAL < nsNA | 1 | 10 | 3.39 | 0.007 | 1.96 |
| L supramarginal | sNA < nsNA | 1 | 9 | 2.72 | 0.02 | 1.64 |
| L supramarginal | sNA < nsAL | 1 | 9 | 2.94 | 0.02 | 1.77 |
| L temporal pole | sAL < nsNA | 1 | 10 | 2.97 | 0.01 | 1.71 |
| R caudal anterior cingulate | nsNA < sNA | 1 | 9 | 2.31 | 0.05 | 1.39 |
| R caudal middle frontal | nsAL < sNA | 1 | 9 | 2.89 | 0.02 | 1.74 |
| R entorhinal | sNA < nsNA | 1 | 9 | 2.70 | 0.02 | 1.63 |
| R entorhinal | sNA < nsAL | 1 | 9 | 2.28 | 0.05 | 1.37 |
| R pars orbitalis* | sNA < nsNA | 1 | 9 | 3.18 | 0.01 | 1.92 |
| R precentral | sAL < sNA | 1 | 9 | 2.46 | 0.04 | 1.48 |
| R precentral | sAL < nsNA | 1 | 10 | 2.63 | 0.02 | 1.52 |
| R rostral middle frontal | nsNA < nsAL | 1 | 10 | 2.91 | 0.02 | 1.68 |
| R superior parietal | nsAL < nsNA | 1 | 10 | 3.09 | 0.01 | 1.78 |
| R temporal pole | nsAL < sAL | 1 | 10 | 2.93 | 0.01 | 1.69 |
| R temporal pole | nsAL < nsNA | 1 | 10 | 2.36 | 0.04 | 1.36 |
| L total cortex | sNA < nsNA | 1 | 9 | 2.31 | 0.05 | 1.39 |
| L middle temporal WM* | nsNA < sNA | 1 | 9 | 2.33 | 0.04 | 1.41 |
| R banks of the superior temporal sulcus WM* | sAL < nsAL | 1 | 10 | 2.77 | 0.02 | 1.60 |
| R banks of the superior temporal sulcus WM* | sAL < sNA | 1 | 9 | 2.46 | 0.04 | 1.48 |
| R caudal anterior cingulate WM | nsNA < sNA | 1 | 9 | 2.41 | 0.04 | 1.45 |
| R caudal middle frontal WM | nsAL < nsNA | 1 | 10 | 2.33 | 0.04 | 1.35 |
| R caudal middle frontal WM | nsAL < sNA | 1 | 9 | 2.89 | 0.02 | 1.74 |
| R fusiform WM | nsAL < sNA | 1 | 9 | 2.38 | 0.04 | 1.44 |
| R inferior temporal WM | nsNA < nsAL | 1 | 10 | 2.42 | 0.04 | 1.40 |
| R rostral middle frontal WM | nsNA < nsAL | 1 | 10 | 4.36 | 0.001 | 2.52 |
| R rostral middle frontal WM | nsNA < sAL | 1 | 10 | 2.27 | 0.05 | 1.31 |
Notes: For each contrast, degrees of freedom (df), t, P, and Cohen’s d are presented. Cohen’s d was calculated with the following formula: 2t/√(N – 2)
Significant interactions between smoking and alcoholism, where P<0.05. In purple: comorbid effects (sAL versus nsNA). In red: smoking effects (sAL versus nsAL or sNA versus nsNA). In blue: alcholism effects (sAL versus sNA or nsAL versus nsNA). In green: cross effects of smoking and alcoholism (sNA versus nsAL).
Abbreviations: L, left hemisphere; R, right hemisphere; nsAL, alcoholic participants – currently not smoking; nsNA, nonalcoholic participants – currently not smoking; sAL, alcoholic participants (the comorbid group); sNA, nonalcoholic participants – current smokers; WM, white matter.